The structural basis for the oriented assembly of a TBP/TFB/promoter complex.

@article{Littlefield1999TheSB,
  title={The structural basis for the oriented assembly of a TBP/TFB/promoter complex.},
  author={Otis Littlefield and Yakov Korkhin and Paul B. Sigler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 24},
  pages={13668-73}
}
Recently the definition of the metazoan RNA polymerase II and archaeal core promoters has been expanded to include a region immediately upstream of the TATA box called the B recognition element (BRE), so named because eukaryal transcription factor TFIIB and its archaeal orthologue TFB interact with the element in a sequence-specific manner. Here we present the 2.4-A crystal structure of archaeal TBP and the C-terminal core of TFB (TFB(c)) in a complex with an extended TATA-box-containing… CONTINUE READING

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