The structural basis for the intrinsic disorder of the actin filament: the "lateral slipping" model

@article{Bremer1991TheSB,
  title={The structural basis for the intrinsic disorder of the actin filament: the "lateral slipping" model},
  author={Alfonso Bremer and R. C. Millonig and Rosmarie Suetterlin and Andreas Engel and Thomas D. Pollard and Ueli Aebi},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={115},
  pages={689 - 703}
}
Three-dimensional (3-D) helical reconstructions computed from electron micrographs of negatively stained dispersed F-actin filaments invariably revealed two uninterrupted columns of mass forming the "backbone" of the double-helical filament. The contact between neighboring subunits along the thus defined two long-pitch helical strands was spatially conserved and of high mass density, while the intersubunit contact between them was of lower mass density and varied among reconstructions. In… CONTINUE READING