The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

@article{Brown1999TheSB,
  title={The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases},
  author={Nick R. Brown and Martin E. M. Noble and Jane A. Endicott and Louise N. Johnson},
  journal={Nature Cell Biology},
  year={1999},
  volume={1},
  pages={438-443}
}
Progression through the eukaryotic cell cycle is driven by the orderly activation of cyclin-dependent kinases (CDKs). For activity, CDKs require association with a cyclin and phosphorylation by a separate protein kinase at a conserved threonine residue (T160 in CDK2). Here we present the structure of a complex consisting of phosphorylated CDK2 and cyclin A together with an optimal peptide substrate, HHASPRK. This structure provides an explanation for the specificity of CDK2 towards the proline… 
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