The structural basis for serotype-specific neutralization of dengue virus by a human antibody.

  title={The structural basis for serotype-specific neutralization of dengue virus by a human antibody.},
  author={Ee Ping Teoh and Petra Kukkaro and En Wei Teo and Angeline Pei Chiew Lim and Tze Tong Terence Tan and Andy Yip and Wouter Schul and Myint Oo Aung and Victor A. Kostyuchenko and Yee Sin Leo and Soh Ha Chan and Kenneth G C Smith and Annie Hoi Yi Chan and Gang Zou and Eng Eong Ooi and David M Kemeny and Grace Kx Tan and Jowin Kai Wei Ng and Mah Lee Mary Ng and S. Miguel Alonso and Dale Fisher and Pei-Yong Shi and Brendon John Hanson and S M Lok and Paul A MacAry},
  journal={Science translational medicine},
  volume={4 139},
Dengue virus (DENV) is a mosquito-borne flavivirus that affects 2.5 billion people worldwide. There are four dengue serotypes (DENV1 to DENV4), and infection with one elicits lifelong immunity to that serotype but offers only transient protection against the other serotypes. Identification of the protective determinants of the human antibody response to DENV is a vital requirement for the design and evaluation of future preventative therapies and treatments. Here, we describe the isolation of a… CONTINUE READING
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