The structural basis for kainoid selectivity at AMPA receptors revealed by low-mode docking calculations.

@article{Carcache2003TheSB,
  title={The structural basis for kainoid selectivity at AMPA receptors revealed by low-mode docking calculations.},
  author={Luis M Carcache and Jonierr Rodriguez and Kathleen S. Rein},
  journal={Bioorganic & medicinal chemistry},
  year={2003},
  volume={11 4},
  pages={551-9}
}
The kainoids are a class of excitatory and excitotoxic pyrrolidine dicarboxylates that act at ionotropic glutamate receptors. The kainoids bind kainate receptors with high affinity and, while binding affinity is lower at AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, they are active in functional assays at this receptor subtype as well. However, kainoids are only partial agonists at AMPA receptors. Currents evoked by kainoids have been described as either slowly… CONTINUE READING