The structural basis for control of eukaryotic protein kinases.

@article{Endicott2012TheSB,
  title={The structural basis for control of eukaryotic protein kinases.},
  author={Jane A Endicott and Martin E. M. Noble and Louise N. Johnson},
  journal={Annual review of biochemistry},
  year={2012},
  volume={81},
  pages={587-613}
}
Eukaryotic protein kinases are key regulators of cell processes. Comparison of the structures of protein kinase domains, both alone and in complexes, allows generalizations to be made about the mechanisms that regulate protein kinase activation. Protein kinases in the active state adopt a catalytically competent conformation upon binding of both the ATP and peptide substrates that has led to an understanding of the catalytic mechanism. Docking sites remote from the catalytic site are a key… CONTINUE READING
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