The structural bases of the processive degradation of iota-carrageenan, a main cell wall polysaccharide of red algae.

@article{Michel2003TheSB,
  title={The structural bases of the processive degradation of iota-carrageenan, a main cell wall polysaccharide of red algae.},
  author={Gurvan Michel and William Helbert and Richard Kahn and Otto Dideberg and Bernard Kloareg},
  journal={Journal of molecular biology},
  year={2003},
  volume={334 3},
  pages={421-33}
}
iota-Carrageenans are sulfated 1,3-alpha-1,4-beta-galactans from the cell walls of red algae, which auto-associate into crystalline fibers made of aggregates of double-stranded helices. iota-Carrageenases, which constitute family 82 of glycoside hydrolases, fold into a right-handed beta-helix. Here, the structure of Alteromonas fortis iota-carrageenase bound to iota-carrageenan fragments was solved at 2.0A resolution (PDB 1KTW). The enzyme holds a iota-carrageenan tetrasaccharide (subsites +1… CONTINUE READING
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