The structural and functional units of heteromeric amino acid transporters. The heavy subunit rBAT dictates oligomerization of the heteromeric amino acid transporters.

@article{Fernndez2006TheSA,
  title={The structural and functional units of heteromeric amino acid transporters. The heavy subunit rBAT dictates oligomerization of the heteromeric amino acid transporters.},
  author={Esperanza Romero Fern{\'a}ndez and Maite Jim{\'e}nez-Vidal and Mar{\'i}a Calvo and Antonio Zorzano and Francesc Tebar and Manuel Palac{\'i}n and Josep Chillar{\'o}n},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 36},
  pages={26552-61}
}
Heteromeric amino acid transporters are composed of a catalytic light subunit and a heavy subunit linked by a disulfide bridge. We analyzed the structural and functional units of systems b0,+ and xC-, formed by the heterodimers b0,+ AT-rBAT and xCT-4F2hc, respectively. Blue Native gel electrophoresis, cross-linking, and fluorescence resonance energy transfer in vivo indicate that system b0,+ is a heterotetramer [b0,+ AT-rBAT]2, whereas xCT-4F2hc seems not to stably or efficiently oligomerize… CONTINUE READING
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