The strong inhibition of triosephosphate isomerase by the natural beta-carbolines may explain their neurotoxic actions.

@article{Bonnet2004TheSI,
  title={The strong inhibition of triosephosphate isomerase by the natural beta-carbolines may explain their neurotoxic actions.},
  author={Ragnhild Bonnet and Sanja Pavlovic and Jessica Lehmann and Hans Rommelspacher},
  journal={Neuroscience},
  year={2004},
  volume={127 2},
  pages={443-53}
}
The natural beta-carbolines (BC) closely resemble the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in structure. The N-methylated beta-carbolinium ions (BC+) are potent inhibitors of mitochondrial respiration and are nigrostriatal neurotoxins. Utilizing [3H]BC, we have identified several proteins to which BC binds with high affinity (e.g. the chaperone member glucose regulated protein 78, the enzyme carboxylesterase, the cytochrome P450 2E1, the enzyme monoamine oxidase B and… CONTINUE READING
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