The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques.

@article{AbiYounes2000TheSC,
  title={The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques.},
  author={S A Abi-Younes and Alain Sauty and François Mach and Galina K Sukhova and P. Scott Libby and Andrew D Luster},
  journal={Circulation research},
  year={2000},
  volume={86 2},
  pages={131-8}
}
Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. However, their role in modulating platelet function has not been shown. We studied the direct effect of chemokines on human platelets and found that of the 16 tested only stromal cell-derived factor (SDF)-1 induced platelet aggregation, accompanied by a rise in intracellular calcium. Platelets expressed the SDF-1 receptor, CXCR4, and an antibody to CXCR4 and pertussis toxin inhibited SDF-1-induced… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 122 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Similar Papers

Loading similar papers…