The stressed neonatal kidney: from pathophysiology to clinical management of neonatal vasomotor nephropathy

@article{TthHeyn2000TheSN,
  title={The stressed neonatal kidney: from pathophysiology to clinical management of neonatal vasomotor nephropathy},
  author={P{\'e}ter T{\'o}th-Heyn and Alfred Drukker and J. -P. Guignard},
  journal={Pediatric Nephrology},
  year={2000},
  volume={14},
  pages={227-239}
}
The healthy term, and particularly the premature infant, is born with a very low glomerular filtration rate (GFR), controlled by a delicate balance of intrarenal vasoconstrictor and vasodilator forces. Vasoactive disturbances can easily further reduce the already low GFR. The newborn infant is thus prone to develop vasomotor nephropathy (VMNP) or acute renal failure (ARF). The main causes for ARF at this young age are prerenal mechanisms, and include hypotension, hypovolemia, hypoxemia… CONTINUE READING