The stressed host response to infection: the disruptive signals and rhythms of systemic inflammation.

@article{Lowry2009TheSH,
  title={The stressed host response to infection: the disruptive signals and rhythms of systemic inflammation.},
  author={Stephen F. Lowry},
  journal={The Surgical clinics of North America},
  year={2009},
  volume={89 2},
  pages={311-26, vii}
}
The cognate signals from sterile or pathogen-induced sources converge on the same recognition or response pathways. In the surgical patient, a systemic response to infection most often occurs in the context of ongoing inflammatory stress. Such an inflammatory response is modulated initially by the magnitude of injury and by patient-specific (endogenous) factors, such as confounding illness, age, and genetic variation. Over an extended period of stress, treatmentrelated (exogenous) factors add… CONTINUE READING

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