The stress response: implications for the clinical development of hsp90 inhibitors.

@article{Whitesell2003TheSR,
  title={The stress response: implications for the clinical development of hsp90 inhibitors.},
  author={Luke Whitesell and Rochelle Bagatell and Ryan R. Falsey},
  journal={Current cancer drug targets},
  year={2003},
  volume={3 5},
  pages={349-58}
}
In their role as molecular chaperones, heat shock proteins serve as central integrators of protein homeostasis within cells. As part of this function, they guide the folding, assembly, intracellular disposition and proteolytic turnover of many key regulators of cell growth, differentiation and survival. Not surprisingly then, heat shock proteins are over expressed in many types of cancer, and induction of the stress response may actually be required for cells to tolerate the genetic disarray… CONTINUE READING