The stress of weaning influences serum levels of acute-phase proteins, iron-binding proteins, inflammatory cytokines, cortisol, and leukocyte subsets in Holstein calves

@article{Kim2011TheSO,
  title={The stress of weaning influences serum levels of acute-phase proteins, iron-binding proteins, inflammatory cytokines, cortisol, and leukocyte subsets in Holstein calves},
  author={Myung Hoo Kim and Jiyoung Yang and Santi Devi Upadhaya and Hyun-Jun Lee and Cheol-Heui Yun and Jong K. Ha},
  journal={Journal of Veterinary Science},
  year={2011},
  volume={12},
  pages={151 - 157}
}
The purpose of our study was to investigate changes in immunological parameters induced by weaning stress (including milk restriction) in calves. Fifteen Holstein calves were subjected to weaning at 6 weeks of age. Blood samples were collected at -14, -7, -2, 1, 3, and 5 days post-weaning (DPW; 0 DPW = 42 days). Weaning caused significant (p < 0.01) increases in the neutrophil (NE):lymphocyte (LY) ratio at 5 DPW with a significant (p < 0.05) reduction of LYs. The concentration of acute-phase… 
View PDF
96 Citations
Highly Influential Citations
7
Background Citations
37
Methods Citations
1
Results Citations
9

Tables from this paper

96 Citations

Stress Response at different Ages of Weaning in Cattle
TLDR
Leukocyte subsets, plasmatic proteins, cortisol levels, and immune status were altered after weaning challenge in both studied age groups of calves, indicating weaning as a stressor, regardless of age.
Stress, acute phase proteins and immune modulation in calves
TLDR
The focus of this review is on the aetiology of the responses in calves under severe stress and its impact on growth and immune status and possible strategies to alleviate this condition including the role of specific feed additives are presented.
Interleukin-1Ra (Il-1Ra) and serum cortisol level relationship in horse as dynamic adaptive response during physical exercise.
Evaluation of Possible Stress Factors Affecting Physiological Level of Gamma Interferon During First Six Months of Life in Healthy Calves
TLDR
Normal physiological level of INFγ in calves positively increased during 1-2 months after birth, positively correlated with gender mainly females; drinking of tap water; milk feeding; and breeding of calves in poor health status of environment.
An intensive milk replacer feeding program benefits immune response and intestinal microbiota of lambs during weaning
TLDR
It is revealed that weaning stress induced alterations to the lambs’ immune system that lasted beyond the 21 d measured, and that a long-term inflammatory response effect was evidenced by changes in their hematological and expressed pro-inflammatory cytokines.
Identification of some plasma biomarkers associated with early weaning stress in crossbred piglets
TLDR
It is concluded that MCP-1, Hp, and HMGB1 protein are the potential biomarkers besides NOx and IL-1β which are the sensitive indicator of physiological stress in early weaned piglets.
Influence of selenium administration to dry cows on selected biochemical and immune parameters of their offspring.
TLDR
A single injection of a selenium supplement administered to cows during late pregnancy increases selenum levels in calves and enhances passive transfer from the mother to the offspring.
The Combined Effect of Weaning Stress and Immune Activation during Pig Gestation on Serum Cytokine and Analyte Concentrations
TLDR
The results indicate that maternal immune activation may grant higher tolerance to anion gap and bilirubin disruptions triggered by weaning stress, indicating that management practices aimed at minimizing the effects of weaning should consider the interacting effect of immune activation during development.
Stress-related hormonal alterations, growth and pelleted starter intake in pre-weaning Holstein calves in response to thermal stress
TLDR
It was concluded that in this particular environment, heat stress affects birth weight and growth rate of Holstein calves and environmental management of the newborn calf during hot spring and summer months is warranted to optimize pelleted starter intake and calf growth rates.
Examination of the effect of weaning stress on the physiological and molecular regulation of immune function in circulating bovine leukocytes
TLDR
It is demonstrated that stress can have accumulative effects and by combining housing with weaning, an increase in neutrophil number and decrease in lymphocyte number was found and the identification of novel biomarkers and regulatory gene networks that are stress activated provides a mechanistic framework to characterise the multifaceted nature of weaning stress adaptation in beef calves.
...
...

References

SHOWING 1-10 OF 39 REFERENCES
The effect of abrupt weaning of suckler calves on the plasma concentrations of cortisol, catecholamines, leukocytes, acute-phase proteins and in vitro interferon-gamma production.
TLDR
Abrupt weaning increased plasma cortisol and noradrenaline concentrations that were accompanied by attenuation of in vitro interferon-gamma production to novel mitogen and antigen complexes up to 7 d after weaning.
THE EFFECT OF THE STRESS OF WEANING AND TRANSPORT ON WHITE BLOOD CELL PATTERNS AND FIBRINOGEN CONCENTRATION OF BEEF CALVES OF DIFFERENT GENOTYPES
TLDR
Genotype of the calf did not alter the fibrinogen concentration, the number of leukocytes or the distribution of the leukocyte population, according to the stressors of weaning and transport of four distinct genotypes of beef calves.
The Effect of Dexamethasone on Some Immunological Parameters in Cattle
TLDR
The results indicate the potential for haematology and immune function assays to reflect elevated activity of the hypothalamic–pituitary–adrenocortical axis in cattle and Immunological parameters may provide a useful adjunct to cortisol and behavioural observations for assessing the impact of stress on the welfare of cattle.
Effects of age and nutrition on expression of CD25, CD44, and L-selectin (CD62L) on T-cells from neonatal calves.
TLDR
The results indicate that the functional capacity of the calf's T-cell population becomes more adult-like during the first weeks of life and suggest that nutrition modulates T- cell function during this period of immune maturation.
Regulation of neutrophil adhesion molecules and shedding of Staphylococcus aureus in milk of cortisol- and dexamethasone-treated cows
TLDR
The results suggest that mammary gland health status can be altered by sudden exposure of blood neutrophils to glucocorticoids, because these steroid hormones caused profound down-regulation of the adhesion molecules that direct neutrophil margination and migration through the vascular endothelium.
Regulation of neutrophil adhesion molecules and shedding of Staphylococcus aureus in milk of cortisol- and dexamethasone-treated cows.
TLDR
The results suggest that mammary gland health status can be altered by sudden exposure of blood neutrophils to glucocorticoids, because these steroid hormones caused profound down-regulation of the adhesion molecules that direct neutrophil margination and migration through the vascular endothelium.
Immune Response and Plasma Alpha Tocopherol and Selenium Status of Male Buffalo (Bubalus bubalis) Calves Supplemented with Vitamin E and Selenium
TLDR
It was concluded that vitamin E and Se supplementation improved the status of these micronutrients and humoral immune response in buffalo calves and showed a tendency towards improvement in cell mediated immune response.
IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo.
TLDR
The notion that direct interaction of IL-6 with the liver is an essential part in initiating the hepatic acute phase reaction is supported.
Effect of transportation and commingling on the acute-phase protein response, growth, and feed intake of newly weaned beef calves.
TLDR
The results of these studies indicate that stressors associated with transportation affect the acute-phase protein response in newly weaned beef calves and whether these proteins might be valuable indicators of stress following the weaning process is needed.
Influence of experimentally induced endogenous production of cortisol on the immune capacity in swine
...
...