The stress of starvation: glucocorticoid restraint of beta cell development


Developmental insults during gestation, such as under-nutrition, are known to restrict the number of beta cells that form in the fetal pancreas and are maintained in adulthood, leading to increased risk of type 2 diabetes. There are now substantial data indicating that glucocorticoids mediate this effect of under-nutrition on beta cell mass and that even at… (More)
DOI: 10.1007/s00125-010-1963-x