The stress-inducible transcription factor ATF4 accumulates at specific rRNA-processing nucleolar regions after proteasome inhibition.

@article{Galimberti2016TheST,
  title={The stress-inducible transcription factor ATF4 accumulates at specific rRNA-processing nucleolar regions after proteasome inhibition.},
  author={Valentina Galimberti and Noa Kinor and Yaron Shav-Tal and Marco Biggiogera and A. M. Bruening},
  journal={European journal of cell biology},
  year={2016},
  volume={95 10},
  pages={389-400}
}
Functional protein homeostasis is essential for the maintenance of normal cellular physiology, cell growth, and cell survival. Proteasome inhibition in cancer cells can disturb protein homeostasis in such a way that synthetic proteasome inhibitors like bortezomib may selectively kill myeloma cells. Solid cancer cells appear to respond less to bortezomib… CONTINUE READING