The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes.

@article{Wei2003TheSR,
  title={The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes.},
  author={Michael Wei and Leslie G T Ong and Maree T Smith and Fraser B Ross and Katrina Schmid and Andrew J Hoey and Darryl John Burstow and Lindsay Brown},
  journal={Heart, lung & circulation},
  year={2003},
  volume={12 1},
  pages={44-50}
}
BACKGROUND Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes is streptozotocin (STZ)-induced diabetes in the rat. METHODS This project assessed cardiovascular, ocular and neuropathic changes over a period of 24 weeks post STZ administration in rats. RESULTS STZ-diabetic rats (n = 96) showed stable signs of diabetes (hyperglycaemia, increased water and food… CONTINUE READING

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The impact of metabolic and blood pressure control on incidence and progression of nephropathy. A 10-year study of 385 type 2 diabetic patients

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