The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune response.

@article{Kaiser2012TheSM,
  title={The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune response.},
  author={Patrick Kaiser and M{\'e}d{\'e}ric Diard and B{\"a}rbel Stecher and Wolf-Dietrich Hardt},
  journal={Immunological reviews},
  year={2012},
  volume={245 1},
  pages={56-83}
}
The mammalian intestine is colonized by a dense microbial community, the microbiota. Homeostatic and symbiotic interactions facilitate the peaceful co-existence between the microbiota and the host, and inhibit colonization by most incoming pathogens ('colonization resistance'). However, if pathogenic intruders overcome colonization resistance, a fierce, innate inflammatory defense can be mounted within hours, the adaptive arm of the immune system is initiated, and the pathogen is fought back… CONTINUE READING