The streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization.

@article{Hermans2006TheSL,
  title={The streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization.},
  author={Peter Hermans and Peter V. Adrian and Christa Albert and Silvia C Estev{\~a}o and Theo Hoogenboezem and Ingrid H T Luijendijk and Thilo Kamphausen and Sven Hammerschmidt},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 2},
  pages={968-76}
}
Streptococcus pneumoniae expresses two surface-exposed lipoproteins, PpmA and SlrA, which share homology with distinct families of peptidyl-prolyl isomerases (PPIases). In this study, we demonstrated for the first time that the lipoprotein cyclophilin, SlrA, can catalyze the cis-trans isomerization of proline containing tetrapeptides and that SlrA contributes to pneumococcal colonization. The substrate specificity of SlrA is typical for prokaryotic and eukaryotic cyclophilins, with Suc-Ala-Ala… CONTINUE READING
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