The strength of genetic interactions scales weakly with mutational effects

@article{Velenich2013TheSO,
  title={The strength of genetic interactions scales weakly with mutational effects},
  author={Andrea Velenich and Jeff Gore},
  journal={Genome Biology},
  year={2013},
  volume={14},
  pages={R76 - R76}
}
BackgroundGenetic interactions pervade every aspect of biology, from evolutionary theory, where they determine the accessibility of evolutionary paths, to medicine, where they can contribute to complex genetic diseases. Until very recently, studies on epistatic interactions have been based on a handful of mutations, providing at best anecdotal evidence about the frequency and the typical strength of genetic interactions. In this study, we analyze a publicly available dataset that contains the… 

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