The stratum corneum: structure and function in health and disease

@article{Harding2004TheSC,
  title={The stratum corneum: structure and function in health and disease},
  author={Clive Roderick Harding},
  journal={Dermatologic Therapy},
  year={2004},
  volume={17}
}
  • C. Harding
  • Published 21 January 2004
  • Chemistry
  • Dermatologic Therapy
ABSTRACT:  Our understanding of the formation, structure, composition, and maturation of the stratum corneum (SC) has progressed enormously over the past 30 years. Today, there is a growing realization that this structure, while faithfully providing a truly magnificent barrier to water loss, is a unique, intricate biosensor that responds to environmental challenges and surface trauma by initiating a series of biologic processes which rapidly seek to repair the damage and restore barrier… 
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283 Citations
Highly Influential Citations
15
Background Citations
88
Methods Citations
3
Results Citations
2

283 Citations

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This article provides a thorough "primer" for the clinician, reviewing the multiple normal homeostatic functions of the stratum corneum and the cutaneous challenges that arise when individual functions of this thin yet very active epidermal layer are compromised by exogenous and/or endogenous factors.
Understanding age-induced alterations to the biomechanical barrier function of human stratum corneum.
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It is thus very important to investigate biological mechanisms involved in Inflamm'dryness to better manage dry skin.
Structure and function of the epidermal barrier
Skin Lipids in Health and Disease: A Review.
Barrier Disease Beyond Eczema : Management of Juvenile Plantar Dermatitis with a Physiologic Barrier Repair Cream
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A closer look at the diagnosis and management of two cutaneous conditions influenced by barrier dysfunction: juvenile plantar dermatitis or wet-to-dry foot syndrome, and head and neck dermatitis.
Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis
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This review summarizes recent discoveries on the origin of the skin barrier alterations in AD at the structural protein level, including hereditary and acquired components.
Biomechanics of the Barrier Function of Human Stratum Corneum
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This chapter describes how the drying stresses that develop in SC provide a mechanical driving force for dry skin damage such as chapping and cracking and demonstrates how damaging treatments enhance and moisturizing treatments alleviate the propensity for dryskin damage.
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