The story of penicillamine: A difficult birth

@article{Walshe2003TheSO,
  title={The story of penicillamine: A difficult birth},
  author={J. Walshe},
  journal={Movement Disorders},
  year={2003},
  volume={18}
}
  • J. Walshe
  • Published 2003
  • Medicine
  • Movement Disorders
It is often said, somewhat cynically, of a newly introduced drug, “use it while it still works.” With penicillamine the opposite was the case. This chelating agent, introduced in 1956,1 not only revolutionised the treatment of Wilson’s disease, but subsequently found a use in the management of cystinuria and rheumatoid arthritis. Penicillamine, dimethyl cysteine, was originally derived from penicillin by hydrolysis breaking the lactam ring. In the first description of this molecule by Abraham… Expand

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References

SHOWING 1-10 OF 27 REFERENCES
Penicillamine, a new oral therapy for Wilson's disease.
  • J. Walshe
  • Medicine
  • The American journal of medicine
  • 1956
The effect of chelation therapy on the amino aciduria and peptiduria of Wilson's disease.
Wilson's disease and BAL
  • Neurology
  • 2002
Wilson’s disease and BAL (British antilewisite [2,3-dimercaptopropanolol])
  • Neurology
  • 2002
Copper: its role in the pathogenesis of liver disease.
  • J. Walshe
  • Medicine
  • Seminars in liver disease
  • 1984
De hepato-cerebrale degeneratie. Arnhem: Van der Wiel
  • 1961
...
1
2
3
...