The story of an exceptional serine protease, tissue-type plasminogen activator (tPA).

@article{Hebert2016TheSO,
  title={The story of an exceptional serine protease, tissue-type plasminogen activator (tPA).},
  author={Marie J Hebert and Flavie Lesept and Denis Vivien and Richard Macrez},
  journal={Revue neurologique},
  year={2016},
  volume={172 3},
  pages={186-97}
}
The only acute treatment of ischemic stroke approved by the health authorities is tissue recombinant plasminogen activator (tPA)-induced thrombolysis. Under physiological conditions, tPA, belonging to the serine protease family, is secreted by endothelial and brain cells (neurons, astrocytes, microglia, oligodendrocytes). Although revascularisation induced by tPA is beneficial during a stroke, research over the past 20 years shows that tPA can also be deleterious for the brain parenchyma. Thus… CONTINUE READING