The story of Notch and chronic kidney disease.

  title={The story of Notch and chronic kidney disease.},
  author={Shuchita Sharma and Yasemin Sirin and Katalin Suszt{\'a}k},
  journal={Current opinion in nephrology and hypertension},
  volume={20 1},
PURPOSE OF REVIEW The Notch pathway is an evolutionary conserved cell-cell communication mechanism that plays a key role in kidney development. Here, we will discuss a number of recently published papers describing the role of Notch signaling in kidney development, homeostasis, injury and repair. RECENT FINDINGS Recent gene expression studies identified regulation of the Notch pathway in patients with chronic kidney disease (CKD). Mechanistic experiments performed using transgenic and knock… CONTINUE READING
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