The stochastic dynamics of filopodial growth.

  title={The stochastic dynamics of filopodial growth.},
  author={Yueheng Lan and Garegin A. Papoian},
  journal={Biophysical journal},
  volume={94 10},
A filopodium is a cytoplasmic projection, exquisitely built and regulated, which extends from the leading edge of the migrating cell, exploring the cell's neighborhood. Commonly, filopodia grow and retract after their initiation, exhibiting rich dynamical behaviors. We model the growth of a filopodium based on a stochastic description which incorporates mechanical, physical, and biochemical components. Our model provides a full stochastic treatment of the actin monomer diffusion and… CONTINUE READING