The stimulus-secretion coupling of glucose-induced insulin release: fuel metabolism in islets deprived of exogenous nutrient.

@article{Malaisse1983TheSC,
  title={The stimulus-secretion coupling of glucose-induced insulin release: fuel metabolism in islets deprived of exogenous nutrient.},
  author={Willy Jean Malaisse and L. L. Best and Shoji Kawazu and Francine Malaisse-Lagae and Abdullah Sener},
  journal={Archives of biochemistry and biophysics},
  year={1983},
  volume={224 1},
  pages={
          102-10
        }
}
The fuel hypothesis for insulin release postulates that the secretory response to nutrient secretagogues reflects their capacity to augment catabolic fluxes in pancreatic islet cells. Hence, both the oxidation of exogenous nutrients and their effect upon the metabolism of endogenous nutrients should be taken into consideration to account for the stimulation of insulin release. In the present work, an attempt was made to quantify the respective contribution of carbohydrates, fatty acids, and… CONTINUE READING
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