The stimulus-secretion coupling of amino acid-induced insulin release

@article{Malaisse2004TheSC,
  title={The stimulus-secretion coupling of amino acid-induced insulin release},
  author={W. Malaisse and A. R. Carpinelli and P. Lebrun and A. Herchuelz and A. Sener},
  journal={Pfl{\"u}gers Archiv},
  year={2004},
  volume={391},
  pages={112-118}
}
  • W. Malaisse, A. R. Carpinelli, +2 authors A. Sener
  • Published 2004
  • Chemistry, Biology
  • Pflügers Archiv
  • Abstractl-Glutamine enhances insulin release evoked byl-leucine in isolated rat pancreatic islets. The enhancing action ofl-glutamine, which is a rapid but steadily increasing and not rapidly reversible phenomenon, is not attributable to any major change in either K+ or Ca2+ outflow from the islet cells. It coincides with an apparent increase in Ca2+ inflow rate and, hence, with Ca accumulation in the islets. The initial ionic response tol-leucine is not qualitatively altered by the presence… CONTINUE READING

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