The stimulatory effect of LXRalpha is blocked by SHP despite the presence of a LXRalpha binding site in the rabbit CYP7A1 promoter.

@article{Shang2006TheSE,
  title={The stimulatory effect of LXRalpha is blocked by SHP despite the presence of a LXRalpha binding site in the rabbit CYP7A1 promoter.},
  author={Q. M. Shang and Luxing Pan and Monica Saumoy and John Y. L. Chiang and G. Stephen Tint and Gerald Salen and Guorong Xu},
  journal={Journal of lipid research},
  year={2006},
  volume={47 5},
  pages={997-1004}
}
The transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1) is greatly decreased in cholesterol-fed rabbits. To determine whether the molecular structure of the promoter is responsible for this downregulation, we cloned the rabbit CYP7A1 promoter, identified the binding sites for alpha-fetoprotein transcription factor (FTF) and liver X receptor (LXRalpha), and studied the effects of FTF, LXRalpha, and SHP on its transcription. Adding LXRalpha/retinoid X receptor together with their… CONTINUE READING

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