The stimulation of uterine complement component C3 gene expression by antiestrogens.

@article{Sundstrom1990TheSO,
  title={The stimulation of uterine complement component C3 gene expression by antiestrogens.},
  author={S A Sundstrom and Barry S. Komm and Qiuxiang Xu and V A Boundy and C. Richard Lyttle},
  journal={Endocrinology},
  year={1990},
  volume={126 3},
  pages={
          1449-56
        }
}
We have previously demonstrated that complement component C3 is regulated by estradiol in the rat uterus. The antiestrogens tamoxifen, LY117018, and LY156758 exert both agonist and antagonist effects on the immature rat uterus. In this study, these three antiestrogens also stimulated an increase in the synthesis and secretion of C3. The combination of LY117018 and estradiol did not increase C3 to a greater extent than LY117018 alone, which suggests a similar mechanism of regulation. The… CONTINUE READING
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