The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme.

@article{Blzquez1999TheSO,
  title={The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme.},
  author={Cristina Bl{\'a}zquez and Cristina De Ram{\'o}n S{\'a}nchez and A. Niampira Daza and Ismael Galve-Roperh and M {\'A}ngeles Guzm{\'a}n},
  journal={Journal of neurochemistry},
  year={1999},
  volume={72 4},
  pages={1759-68}
}
The effects of cannabinoids on ketogenesis in primary cultures of rat astrocytes were studied. Delta9-Tetrahydrocannabinol (THC), the major active component of marijuana, produced a malonyl-CoA-independent stimulation of carnitine palmitoyltransferase I (CPT-I) and ketogenesis from [14C]palmitate. The THC-induced stimulation of ketogenesis was mimicked by the synthetic cannabinoid HU-210 and was prevented by pertussis toxin and the CB1 cannabinoid receptor antagonist SR141716. Experiments… CONTINUE READING
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