The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism.

@article{Beauloye2002TheSO,
  title={The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism.},
  author={Christophe Beauloye and Anne Sophie Marsin and Luc Bertrand and Jean Louis J Vanoverschelde and Mark H. Rider and Louis Hue},
  journal={FEBS letters},
  year={2002},
  volume={531 2},
  pages={324-8}
}
Increasing heart workload stimulates glycolysis by enhancing glucose transport and fructose-2,6-bisphosphate (Fru-2,6-P(2)), the latter resulting from 6-phosphofructo-2-kinase (PFK-2) activation. Here, we investigated whether adenosine monophosphate (AMP)-activated protein kinase (AMPK) mediates PFK-2 activation in hearts submitted to increased workload. When heart work was increased, PFK-2 activity, Fru-2,6-P(2) content and glycolysis increased, whereas the AMP:adenosine triphosphate (ATP) and… CONTINUE READING

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