The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis.

@article{Qin2009TheSR,
  title={The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis.},
  author={Li Qin and Zhaoliang Liu and Hongwu Chen and Jianming M Xu},
  journal={Cancer research},
  year={2009},
  volume={69 9},
  pages={3819-27}
}
In breast cancer, steroid receptor coactivator-1 (SRC-1) expression positively correlates with HER2 expression and poor prognosis. In mouse mammary tumor virus-polyoma middle T (PyMT) breast cancer mouse model, SRC-1 strongly promotes mammary tumor metastasis. However, the molecular targets and mechanisms that mediate the role of SRC-1 in metastasis are unknown. In this study, SRC-1 wild-type (WT) and knockout (KO) cell lines were developed from the mammary tumors of WT/PyMT and KO/PyMT mice… CONTINUE READING

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