The steroid metabolite 16(β)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1

@article{Neunzig2017TheSM,
  title={The steroid metabolite 16($\beta$)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1},
  author={Jens Neunzig and Mohammed Milhim and Lina Schiffer and Yogan Khatri and Josef Zapp and Alberto S{\'a}nchez-Guijo and Michaela F. Hartmann and Stefan A. Wudy and Rita Bernhardt},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2017},
  volume={167},
  pages={182-191}
}
Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H
TLDR
The studies demonstrate that the allelic variants of P450 when present with a variant form of POR may show different activities, and combined effects of variations in both the P450 enzymes as well as in the POR should be considered when genetic data is available.
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This review covers the 22 (of the total of 57) human P450s in Families 5–51 and their substrate selectivity and update and discuss important aspects of each of these 22 P 450s and questions that remain open.
Identification and circumvention of bottlenecks in CYP21A2‐mediated premedrol production using recombinant Escherichia coli
TLDR
This study successfully improved the whole‐cell process in terms of premedrol production by improving the electron supply to CYP21A2 and circumventing substrate inhibition which is presumed to be the main limiting factor of the presented system by developing an improved fed‐batch protocol.
Novel CYP19A1 Mutations Extend the Genotype-Phenotype Correlation and Reveal the Impact on Ovarian Function
TLDR
In girls, aromatase deficiency usually manifests at birth, but diagnosis may also be made because of abnormal pubertal development or ovarian torsion due to (poly)cystic ovaries, which puts the ovary harboring CYP19A1 variants at very high risk to produce cysts with aging and is therefore prone to ovarian tORSion.
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