The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism

@article{Zhou2009TheSA,
  title={The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism
},
  author={Changcheng Zhou and Suman Verma and Bruce Blumberg},
  journal={Nuclear Receptor Signaling},
  year={2009},
  volume={7},
  pages={123 - 49}
}
The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. SXR has an enlarged, flexible, hydrophobic ligand binding domain (LBD) which is remarkably divergent across mammalian species and SXR exhibits considerable differences in its pharmacology among mammals. The broad response profile of SXR has led to the development… CONTINUE READING