The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes

Abstract

BACKGROUND Flobufen (F) is an original nonsteroidal anti-inflammatory drug with one center of chirality. 4-Dihydroflobufen (DHF), compound with two chiral centers, is the main metabolite of F in microsomes and cytosol in all standard laboratory animals. This work describes the biotransformation of F enantiomers and DHF stereoisomers in isolated male guinea… (More)

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@article{Krl2003TheSO, title={The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes}, author={Radim Kr{\'a}l and Lenka Sk{\'a}lov{\'a} and Barbora Szot{\'a}kov{\'a} and Jakub Vel{\'i}k and Ladislava Schroterova and Yogeeta N Bab{\'u} and Vladimir Wsol}, journal={BMC Pharmacology}, year={2003}, volume={3}, pages={5 - 5} }