The stereospecific activation of protein kinase C.

  title={The stereospecific activation of protein kinase C.},
  author={Robert R. Rando and Neal Young},
  journal={Biochemical and biophysical research communications},
  volume={122 2},
Protein kinase C is synergistically activated by the presence of calcium, certain phospholipids and a diacylglycerol. The physiological activation of the enzyme appears to be determined by the availability of the diacylglycerol which is itself a product of (poly) phosphoinositol turnover. It is shown here that the diacylglycerol activation effect is stereospecific, with only the 1,2-sn-diglycerides being active. This demonstrates for the first time a stereospecific effector role for a membrane… CONTINUE READING

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