The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells

@inproceedings{Hansen2016TheSE,
  title={The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells},
  author={Stine Normann Hansen and Natasja Spring Ehlers and Shida Zhu and Mathilde Borg Houlberg Thomsen and Rikke Linnemann Nielsen and Dongbing Liu and Guangbiao Wang and Yong Hou and Xiuqing Zhang and Xun Xu and Lars Bolund and Huanming Yang and Jun Wang and Jose Moreira and Henrik J. Ditzel and Nils Bruenner and Anne-Sofie Schrohl and Jan Stenvang and Ramneek Gupta},
  booktitle={BMC Genomics},
  year={2016}
}
Resistance to taxane-based therapy in breast cancer patients is a major clinical problem that may be addressed through insight of the genomic alterations leading to taxane resistance in breast cancer cells. In the current study we used whole exome sequencing to discover somatic genomic alterations, evolving across evolutionary stages during the acquisition of docetaxel resistance in breast cancer cell lines. Two human breast cancer in vitro models (MCF-7 and MDA-MB-231) of the step-wise… CONTINUE READING
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CONTRA: copy number analysis for targeted resequencing

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