The stem-cell niche theory: lessons from flies

@article{Lin2002TheSN,
  title={The stem-cell niche theory: lessons from flies},
  author={Haifan Lin},
  journal={Nature Reviews Genetics},
  year={2002},
  volume={3},
  pages={931-940}
}
Stem cells are characterized by their ability to self-renew and to produce numerous differentiated cell types, and are directly responsible for generating and maintaining tissues and organs. This property has long been attributed to the instructive signals that stem cells receive from their microenvironment — the so-called 'stem-cell niche'. Studies of stem cells in the Drosophila gonad have yielded much exciting insight into the structure of the niche and the signalling pathways that it… CONTINUE READING
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DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary.

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