The stem cell niche in regenerative medicine.

  title={The stem cell niche in regenerative medicine.},
  author={Amy J. Wagers},
  journal={Cell stem cell},
  volume={10 4},
Stem cells are fundamental units for achieving regenerative therapies, which leads naturally to a theoretical and experimental focus on these cells for therapeutic screening and intervention. A growing body of data in many tissue systems indicates that stem cell function is critically influenced by extrinsic signals derived from the microenvironment, or "niche." In this vein, the stem cell niche represents a significant, and largely untapped, entry point for therapeutic modulation of stem cell… CONTINUE READING
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