The stem-cell niche as an entity of action

@article{Scadden2006TheSN,
  title={The stem-cell niche as an entity of action},
  author={David T Scadden},
  journal={Nature},
  year={2006},
  volume={441},
  pages={1075-1079}
}
Listen to an interview with David Scadden on the stem cells podcast Stem-cell populations are established in ‘niches’ — specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. Yet the… CONTINUE READING
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a niche for insulin gene expression and β cell proliferation

  • Nikolova, G. et al. The vascular basement membrane
  • Dev. Cell 10, 397–405
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