The stem-cell niche as an entity of action

  title={The stem-cell niche as an entity of action},
  author={David T Scadden},
Listen to an interview with David Scadden on the stem cells podcast Stem-cell populations are established in ‘niches’ — specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. Yet the… CONTINUE READING
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