The stem cell factor receptor/c-Kit as a drug target in cancer.

@article{Lennartsson2006TheSC,
  title={The stem cell factor receptor/c-Kit as a drug target in cancer.},
  author={Johan Lennartsson and Lars R{\"o}nnstrand},
  journal={Current cancer drug targets},
  year={2006},
  volume={6 1},
  pages={65-75}
}
Tyrosine phosphorylation has a key role in intracellular signaling. Inappropriate proliferation and survival cues in tumor cells often occur as a consequence of unregulated tyrosine kinase activity. Much of the current development of anti-cancer therapies tries to target causative proteins in a specific manner to minimize side-effects. One attractive group of target proteins is the kinases. c-Kit is a receptor tyrosine kinase that normally controls the function of primitive hematopoietic cells… CONTINUE READING

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Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.

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