The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells

@article{Yasuda2006TheSC,
  title={The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells},
  author={Akira Yasuda and Hirozumi Sawai and Hiroki Takahashi and Nubuo Ochi and Yoichi Matsuo and Hitoshi Funahashi and Mikinori Sato and Y{\^u}ji Okada and Hiromitsu Takeyama and Tadao Manabe},
  journal={Molecular Cancer},
  year={2006},
  volume={5},
  pages={46 - 46}
}
The transmembrane protein c-kit is a receptor tyrosine kinase (KIT) and KIT is expressed in solid tumors and hematological malignancies such as gastrointestinal stromal tumor (GIST), small-cell lung cancer and chronic myelogenous leukemia (CML). KIT plays a critical role in cell proliferation and differentiation and represents a logical therapeutic target in GIST and CML. In pancreatic cancer, c-kit expression has been observed by immunohistochemical techniques. In this study, we examined the… CONTINUE READING
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