The stellate vascular smooth muscle cell phenotype is induced by IL-1β via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation.

Abstract

Atherosclerosis development is associated with morphological changes to intimal cells, leading to a stellate cell phenotype. In this study, we aimed to determine whether and how key pro-atherogenic cytokines present in atherosclerotic plaques (IL-1β, TNFα and IFNγ) could induce this phenotype, as these molecules are known to trigger the transdifferentiation… (More)
DOI: 10.1016/j.bbamcr.2015.09.019

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Cite this paper

@article{Blirando2015TheSV, title={The stellate vascular smooth muscle cell phenotype is induced by IL-1β via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation.}, author={Karl Blirando and R{\'e}gis Blaise and Natalia Gorodnaya and Clotilde Rouxel and Olivier Meilhac and Pierre Vincent and Isabelle Limon}, journal={Biochimica et biophysica acta}, year={2015}, volume={1853 12}, pages={3235-47} }