The state-of-the-art of chromatin immunoprecipitation.

  title={The state-of-the-art of chromatin immunoprecipitation.},
  author={Philippe Collas},
  journal={Methods in molecular biology},
The biological significance of interactions of nuclear proteins with DNA in the context of gene expression, cell differentiation, or disease has immensely been enhanced by the advent of chromatin immunoprecipitation (ChIP). ChIP is a technique whereby a protein of interest is selectively immunoprecipitated from a chromatin preparation to determine the DNA sequences associated with it. ChIP has been widely used to map the localization of post-translationally modified histones, histone variants… CONTINUE READING