The state diagram for cell adhesion mediated by two receptors.

@article{Bhatia2003TheSD,
  title={The state diagram for cell adhesion mediated by two receptors.},
  author={Sujata K Bhatia and Michael R. King and Daniel A. Hammer},
  journal={Biophysical journal},
  year={2003},
  volume={84 4},
  pages={2671-90}
}
Leukocyte recruitment from the bloodstream to surrounding tissues is an essential component of the immune response. Capture of blood-borne leukocytes onto vascular endothelium proceeds via a two-step mechanism, with each step mediated by a distinct receptor-ligand pair. Cells first transiently adhere, or "roll" (via interactions between selectins and sialyl-Lewis-x), and then firmly adhere to the vascular wall (via interactions between integrins and ICAM-1). We have reported that a… CONTINUE READING

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Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.

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