The staphylococcus-specific gene rsr represses agr and virulence in Staphylococcus aureus.

@article{Tamber2010TheSG,
  title={The staphylococcus-specific gene rsr represses agr and virulence in Staphylococcus aureus.},
  author={Sandeep Tamber and Dindo Reyes and Niles P Donegan and Joseph D. Schwartzman and Ambrose L. Cheung and Guido Memmi},
  journal={Infection and immunity},
  year={2010},
  volume={78 10},
  pages={4384-91}
}
The expression of virulence factors in Staphylococcus aureus is tightly coordinated by a vast network of regulatory molecules. In this report, we characterize a genetic locus unique to staphylococci called rsr that has a role in repressing two key virulence regulators, sarR and agr. Using strain SH1000, we showed that the transcription of virulence effectors, such as hla, sspA, and spa, is altered in an rsr mutant in a way consistent with agr upregulation. Analysis of RNAIII expression of the… CONTINUE READING