The standardized functional observational battery: Its intrinsic value remains in the instrument of measure: The rat.

Abstract

The International Conference on Harmonisation's (ICH) Tripartite Guideline on Safety Pharmacology Studies for Human Pharmaceuticals has adopted the requirement that each new test substance must be tested for effects on the central nervous system prior to "first dose in man". This assessment is required to measure, at a minimum, the effects of the substance… (More)
DOI: 10.1016/j.vascn.2016.08.001

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