The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α.

@article{Santangelo2011TheSR,
  title={The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α.},
  author={Laura Santangelo and Alessandra Marchetti and Carla Cicchini and Alice Conigliaro and Beatrice Conti and Carmine Mancone and Jessica A. Bonzo and Frank J. Gonzalez and Tonino Alonzi and Laura Amicone and Marco Tripodi},
  journal={Hepatology},
  year={2011},
  volume={53 6},
  pages={2063-74}
}
UNLABELLED The concept that cellular terminal differentiation is stably maintained once development is complete has been questioned by numerous observations showing that differentiated epithelium may undergo an epithelial-to-mesenchymal transition (EMT) program. EMT and the reverse process, mesenchymal-to-epithelial transition (MET), are typical events of development, tissue repair, and tumor progression. In this study, we aimed to clarify the molecular mechanisms underlying these phenotypic… CONTINUE READING

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