The stabilization of vancomycin by peptidoglycan analogs.

  title={The stabilization of vancomycin by peptidoglycan analogs.},
  author={Constance M. Harris and Hana Kopecka and Thomas M. Harris},
  journal={The Journal of antibiotics},
  volume={38 1},
The glycopeptide antibiotic vancomycin is unstable in solution. It undergoes a rearrangement involving the conversion of an asparagine residue to isoaspartate to give an antibiotically inactive species, CDP-I. Peptide analogs of bacterial peptidoglycan, such as Ac-D-Ala-D-Ala and di-Ac-L-Lys-D-Ala-D-Ala bind to vancomycin and stabilize the antibiotic against degradation and consequent loss of activity. Protection by peptide is effective even under prolonged heating at 80 degrees C or steam… CONTINUE READING