The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.

@article{Bin2016TheSO,
  title={The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.},
  author={Lucia Bin{\'o} and Jan Ku{\vc}era and Kateřina {\vS}tefkov{\'a} and Lenka {\vS}vih{\'a}lkov{\'a} {\vS}indlerov{\'a} and Martina Kohutkov{\'a} L{\'a}nov{\'a} and Jana Kudov{\'a} and Luk{\'a}{\vs} Kubala and Jiř{\'i} Pachern{\'i}k},
  journal={Chemico-biological interactions},
  year={2016},
  volume={244},
  pages={
          204-14
        }
}
Hypoxic conditions are suggested to affect the differentiation status of stem cells (SC), including embryonic stem cells (ESC). Hypoxia inducible factor (HIF) is one of the main intracellular molecules responsible for the cellular response to hypoxia. Hypoxia stabilizes HIF by inhibiting the activity of HIF prolyl-hydroxylases (PHD), which are responsible for targeting HIF-alpha subunits for proteosomal degradation. To address the impact of HIF stabilization on the maintenance of the stemness… Expand
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